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石津尚明（院長）論文・著書

原著論文

  • Ishizu T, Osoegawa M, Mei FJ, Kikuchi H, Tanaka M, Takakura Y, Minohara M, Murai H, Mihara F, Taniwaki T, Kira J: Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 128: 988-1002, 2005.
  • Ishizu T, Minohara M, Ichiyama T, Kira R, Tanaka M, Osoegawa M, Hara T, Furukawa S, Kira J: CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. J Neuroimmunol 175: 52-58, 2006.
  • Ishizu T, Kira J, Osoegawa M, Fukazawa T, Kikuchi S, Fujihara K, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K; Research Committee of Neuroimmunological Diseases: Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey. J Neurol Sci. 280: 22-28, 2009.
  • Mei FJ, Ishizu T, Murai H, Osoegawa M, Minohara M, Zhang KN, Kira J: Th1 shift CIDP versus Th2 shift in vasculitic neuropathy in CSF. J Neurol Sci. 228: 75-85, 2005.
  • Su JJ, Osoegawa M, Matsuoka T, Minohara M, Tanaka M, Ishizu T, Mihara F, Taniwaki T, Kira J: Upregulation of vascular growth factors in multiple sclerosis: correlation with MRI findings. J Neurol Sci. 243: 21-30, 2006.
  • Mei FJ, Osoegawa M, Ochi H, Minohara M, Nan S, Murai H, Ishizu T, Taniwaki T, Kira J: Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis. J Neurol Sci. 246: 71-77, 2006.
  • Minohara M, Matsuoka T, Li W, Osoegawa M, Ishizu T, Ohyagi Y, Kira J: Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis: positive correlation with disease severity. J Neuroimmunol. 178: 156-160, 2006.
  • Tanaka M, Kikuchi H, Ishizu T, Minohara M, Osoegawa M, Motomura K, Tateishi T, Ohyagi Y, Kira J: Intrathecal upregulation of G-CSF and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 65: 816-825, 2006.
  • Sun X, Minohara M, Kikuchi H, Ishizu T, Tanaka M, Piao H, Osoegawa M, Ohyagi Y, Shimokawa H, Kira J: The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 180: 126-134, 2006.
  • Li W, Minohara M, Su JJ, Matsuoka T, Osoegawa M, Ishizu T, Kira J: Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population. J Neuroimmunol. 184: 227-231, 2007.
  • Matsuoka T, Matsushita T, Kawano Y, Osoegawa M, Ochi H, Ishizu T, Minohara M, Kikuchi H, Mihara F, Ohyagi Y, Kira J: Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese. Brain 130: 1206-1223, 2007.
  • Matsushita T, Matsuoka T, Ishizu T, Kikuchi H, Osoegawa M, Kawano Y, Mihara F, Ohyagi Y, Kira JI: Anterior periventricular linear lesions in optic-spinal multiple sclerosis: a combined neuroimaging and neuropathological study. Mult scler. 14(3): 343-353, 2008.
  • Tanaka M*, Ishizu T*, Ochi H, Kawano Y, Ohyagi Y, Kira J (*equal contribution): Intrathecal upregulation of IFN-g and MIP-1b in juvenile muscular atrophy of the distal upper extremity. J Neurol Sci 275: 74-77, 2008.
  • Shi N, Kawano Y, Matsuoka T, Mei F, Ishizu T, Ohyagi Y, Kira J: Increase of CD4+ TNFa+ IL-2- T cells in cerebrospinal fluid of multiple sclerosis patients. Mult scler. 15(1): 120-123, 2009.
  • Doi H, Matsushita T, Isobe N, Ishizu T, Ohyagi Y, Kira J: Frequency of chronic headaches in Japanese patients with multiple sclerosis: with special reference to opticospinal and common forms of multiple sclerosis. Headache 49(10): 1513-1520, 2009.
  • Matsushita T, Isobe N, Matsuoka T, Shi N, Kawano Y, Wu XM, Yoshiura T, Nakao Y, Ishizu T, Kira JI: Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. Mult scler. 15(7): 834-847, 2009.
  • Matsushita T, Isobe N, Matsuoka T, Ishizu T, Kawano Y, Yoshiura T, Ohyagi Y, Kira J: Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. Mult scler. 15(9): 1113-1117, 2009.
  • Isobe N, Kira J, Kawamura N, Ishizu T, Arimura K, Kawano Y: Neural damage associated with atopic diathesis: a nationwide survey in Japan. Neurology 73(10): 790-797, 2009.
  • Matsushita T, Isobe N, Piao H, Matsuoka T, Ishizu T, Doi H, Masaki K, Yoshiura T, Yamasaki R, Ohyagi Y, Kira J: Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. J Neurol Sci 291: 37-43, 2010.
  • 石津尚明：サイトカイン・ケモカインからみた多発性硬化症の病型と病態．視神経脊髄型多発性硬化症．神経免疫学 13(2): 161-166, 2005.
  • 飛松省三、石津尚明、大庭由宇吾、佐藤伸一郎、菅理恵、加藤元博：上肢および下肢遠位筋の運動誘発電位に対する随意筋収縮の影響．臨床脳波 40(3): 182-187, 1998.

症例報告

  • 石津尚明、大八木保政、古谷博和、荒木武尚、飛松省三、山田猛、吉良潤一：腰部コルセット装着により軽快したrestless legs syndrome/periodic limb movementの1例．臨床神経 41: 438-441, 2001.
  • 廣岡さとみ、立石貴久、石津尚明、大八木保政、吉良潤一：codon 129のMV多型とcodon180点変異を伴った高齢発症の遺伝性Creutzfeldt-Jakob病の1例．神経内科 72: 107-110, 2010.
  • 山下泰治、越智博文、石津尚明、大八木保政、森康雄、荒畑創、大島孝一、吉良潤一：末梢血と骨髄にγ型δ型T細胞のクローン性増多をともなった筋炎の1例．臨床神経 52: 227-233, 2012.

総説・著書

  • 石津尚明：日本人多発性硬化症の特徴からみた診断のポイント．Modern Physician 24(12): 1860-1862, 2004.
  • 石津尚明、吉良潤一：髄液検査．脊椎脊髄ジャーナル 18(5): 640-646, 2005.
  • 石津尚明、吉良潤一：多発性硬化症とIL-17．Current Insights in Neurological Science 14(1): 10-11, 2006.
  • 石津尚明、吉良潤一：アトピー性脊髄炎．Clinical Neuroscience 22(7): 832-833, 2004.
  • Kira J, Ishizu T, Osoegawa M: Multiple sclerosis in Japan: nationwide surveys over 30 years. Neurology Asia 13: 131-143, 2008.
  • Kira J, Matsushita T, Isobe N, Ishizu T: Opticospinal multiple sclerosis in Japanese. Neurology Asia 13: 167-173, 2008.

厚生労働省　免疫性神経疾患に関する調査研究班　班会議

  • 石津尚明、梅風君、小副川学、田中正人、三野原元澄、吉良潤一：視神経脊髄型多発性硬化症における髄液IL-17/IL-8系の活性化：免疫性神経疾患に関する調査研究班．平成16年度班会議
  • 石津尚明、三野原元澄、市山高志、吉良龍太郎、田中正人、小副川学、原寿郎、古川漸、吉良潤一：急性散在性脳脊髄炎の髄液サイトカイン・ケモカインプロフィール：免疫性神経疾患に関する調査研究班．平成16年度班会議
  • 石津尚明、梅風君、小副川学、三野原元澄、村井弘之、吉良潤一：日本人多発性硬化症の臨床病型ごとの髄液および髄液細胞内サイトカイン解析：免疫性神経疾患に関する調査研究班．平成15年度班会議

受賞

  • 公益財団法人　難病医学研究財団　第30回 医学研究奨励助成受賞
  • 日本多発性硬化症協会　平成17年度医学研究助成受賞